BMI Process feb 2020sm

bmiBMI has developed proprietary technology that overcomes immunological, technical, and safety issues associated with the current vaccines, while also enabling a more rapid and lower cost manufacturing process.

ultra-IPV is produced using proprietary inactivation technology. Viruses are complexed with a manganese-decapeptide-phosphate (MDP) mixture and then exposed to UV light. A very quick, easy and reproducible process. The MDP system has been adapted from radiation-resistant bacteria such as Deinococcus radiodurans. 

The use of attenuated Sabin strains to produce the vaccine greatly reduces safety and biosecurity concerns. This non-chemical inactivation process uses ultraviolet light resulting in reduced damage to the immunogenic surface features of the virus.

orangecircleBMI's process is rapid (less than a minute compared with 2-4 weeks for formalin-inactivation) and requires less downstream processing than IPV.
orangecircleultra-IPV vaccine stimulates high titers of virus-neutralizing antibodies in animal models.
orangecircleMass spectrometric analysis of ultra-IPV and two commercially available IPV products indicate that many more doses of ultra-IPV can be made than IPV per starting quantity of virus.
orangecircleultra-IPV is expected to have a similar safety profile as IPV in vaccines with the exception that the use of formaldehyde is avoided.

purplecurvedarrowThe animations below illustrate:

purplecircleChain 1 - VP1 - green;  Chain 2 - VP2 - blue
purplecircleChain 3 - VP3 - red/pink;  Chain 5 - VP3 - orange
purplecircleChain 6 - VP3 - white; Chain 7 - VP2 - white
purplecircleChain 8 - VP1 - orange

Video 1

Video 2

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 BMI is a innov
ative, privately-held vaccine design and development company located in Frederick, Maryland, USA.
Contact Us     Email: polio@bmi-md.com      Phone: (301) 378-2551  Info: Download White Paper
Download our recent publication in PLOS ONE describing the inactivation of polio using gamma irradiation: Click here.

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